Hacat Cell Catalogue number: 300493
HaCaT Cells: A Versatile Model for Dermatological Research
HaCaT cells are a critical tool in dermatological research, offering a reliable platform to investigate the intricate mechanisms of skin biology and pathology. Derived from adult human epidermal cells, this spontaneously immortalized cell line retains the ability to proliferate and differentiate, closely resembling basal keratinocytes in vivo. These attributes make HaCaT cells invaluable for studying epidermal differentiation processes and markers essential for maintaining skin integrity.
The sensitivity of HaCaT cells to apoptosis-inducing agents has made them a standard model for cytotoxicity studies. Researchers frequently use fluorescence microscopy and other techniques to evaluate the effects of apoptosis-inducing agents, such as RIPL, on these cells. Additionally, HaCaT cells are widely utilized to assess the cytotoxicity and efficacy of antimicrobial biomaterials and substrates, including antimicrobial atelocollagen, highlighting their relevance in skin repair and medical applications.
HaCaT cells are also instrumental in exploring cellular senescence, cytokine activity, and gene expression profiles related to aging and chronic diseases. By examining transcriptional profiles, such as the roles of κB and microRNAs, researchers gain insights into molecular regulatory mechanisms and epigenetic influences on keratinocyte differentiation. This includes their involvement in forming the cornified envelope, a crucial component of the skin’s barrier function.
The HaCaT epidermal keratinocyte line enables the study of the complex interplay between keratinocytes and the immune system, particularly in disease states. Their resemblance to basal keratinocytes makes them a tractable system for dissecting these interactions and exploring therapeutic interventions.
In summary, HaCaT cells are indispensable in dermatological and biomedical research. Their applications range from studying epidermal differentiation and skin barrier function to analyzing antimicrobial effects and apoptosis. This versatility underscores their central role in advancing our understanding of skin biology, pathology, and therapeutic development.
Characteristic:
Organism: Human
Tissue: Skin
Age: 62 years
Gender: Male
Ethnicity: Caucasian
Cell type: Keratinocytes with a diameter of 20-25 micrometer.
Growth properties: Adherent
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